Key result
Right atrial appendage tissue from RR homozygotes showed significantly increased inotropic potency to noradrenaline compared to GG homozygotes (-log EC50 6.92 vs 6.36; P<0.005).
Why the study?
Does the 389G>R beta(1)-adrenoceptor polymorphism alter the inotropic and cyclic AMP responses to noradrenaline in isolated human atrial myocardium?
Population
Isolated human right atrial appendage tissue from homozygous RR patients and homozygous GG patients for the…
Comparison
Noradrenaline and isoprenaline exposure to… vs Comparison between tissue from RR homozygotes…
Design
Preclinical
Authors
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RR variant may heighten atrial catecholamine sensitivity; hypothesis-generating and leaves open clinical translation or genotyping utility.
Observational (n=54)
Does the 389G>R beta(1)-adrenoceptor polymorphism alter the inotropic and cyclic AMP responses to noradrenaline in isolated human atrial myocardium?
Absolute Event Rate: 6.92% vs 6.36%
p-value: p=<0.005
The R389 beta(1)-adrenoceptor variant exhibits enhanced G-protein coupling and significantly greater inotropic potency to noradrenaline compared to the G389 variant in native human atrial tissue.
Sandilands et al. (2003) conducted an observational in Patients undergoing elective cardiac surgery (n=54). Homozygous RR genotype (389G>R beta1-adrenoceptor polymorphism) vs. Homozygous GG genotype was evaluated on Inotropic potency to noradrenaline (-log EC50) (p=<0.005). Right atrial appendage tissue from RR homozygotes showed significantly increased inotropic potency to noradrenaline compared to GG homozygotes (-log EC50 6.92 vs 6.36; P<0.005).
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