Key result
In guinea pig Langendorff hearts, SM-20550 (10^-7 M) improved the recovery rate of left ventricular developed pressure after ischemia-reperfusion to 75.9% compared to 36.8% in controls.
Why the study?
Does the selective Na+-H+ exchange inhibitor SM-20550 improve functional and metabolic recovery from ischemia-reperfusion injury in guinea pig Langendorff hearts?
Population
Guinea pig Langendorff hearts subjected to ischemia (40 min) and reperfusion (40 min)
Comparison
SM-20550 10 M or 10 M, or 5--amiloride 10 M vs Drug-free control
Design
Preclinical
Follow-up
40 min reperfusion
Authors
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Supports preclinical testing of Na+-H+ inhibition for cardioprotection; leaves open translation to human ischemia-reperfusion injury.
Does the selective Na+-H+ exchange inhibitor SM-20550 improve functional and metabolic recovery from ischemia-reperfusion injury in guinea pig Langendorff hearts?
Absolute Event Rate: 75.9% vs 36.8%
SM-20550, a selective Na+-H+ exchange inhibitor, protects against ischemia-reperfusion injury by suppressing intracellular Na+ and Ca2+ overload.
Hotta et al. (2001) studied Ischemia-reperfusion injury. SM-20550 vs. Drug-free control was evaluated on Recovery rate of left ventricular developed pressure (LVDP). In guinea pig Langendorff hearts, SM-20550 (10^-7 M) improved the recovery rate of left ventricular developed pressure after ischemia-reperfusion to 75.9% compared to 36.8% in controls.
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