Population
Squid giant axons (and frog striated muscle based on title)
Design
Preclinical
Authors
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Does not warrant clinical use of tetrodotoxin; leaves open whether Na/K currents occupy distinct sites in mammalian neurons.
Tetrodotoxin selectively blocks the initial inward sodium current during spike electrogenesis in squid giant axons, indicating structurally distinct sites for sodium and potassium movement.
Milligan et al. (1965) studied this question.
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