Key result
Subcutaneous infusion of Angiotensin II at 400 ng/kg/min in mice significantly increased mean arterial pressure to 100 mmHg compared to 85 mmHg with vehicle by day 14 (P<0.001).
Population
Mouse model
Comparison
Subcutaneous infusion of angiotensin II at… vs Vehicle
Design
Preclinical
Follow-up
14 days
Authors
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Confirms Ang II mouse model validity for slow pressor hypertension; leaves open whether oxidative stress mechanisms apply to human therapy.
Absolute Event Rate: 100% vs 85%
p-value: p=<0.001
The AngII-infused mouse is a valid model for the slow pressor response, demonstrating that increased oxidative stress mediates the delayed rise in blood pressure and renal vascular resistance.
Kawada et al. (2002) studied Angiotensin II slow pressor response. Angiotensin II vs. Vehicle was evaluated on Mean arterial pressure (MAP) at 14 days (p=<0.001). Subcutaneous infusion of Angiotensin II at 400 ng/kg/min in mice significantly increased mean arterial pressure to 100 mmHg compared to 85 mmHg with vehicle by day 14 (P<0.001).
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