Key result
Stimulation of lymphocytes with protein kinase C activators results in nearly complete loss of surface expression of gp90MEL-14 within 1 hour due to proteolytic cleavage and receptor shedding.
Population
Lymphocytes
Comparison
Activators of protein kinase C such as PMA or… vs Unstimulated normal lymphocytes or pretreatment…
Design
Preclinical
Authors
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May modulate lymphocyte homing in inflammation; leaves open relevance to human cardiovascular disease.
Activation of protein kinase C induces rapid proteolytic cleavage and shedding of the gp90MEL-14 homing receptor on lymphocytes, potentially regulating lymphocyte traffic.
Jung et al. (1990) studied this question. Activators of protein kinase C (PMA or 1-oleoyl 2-acetyl-glycerol) vs. Unstimulated lymphocytes or PKC inhibitors was evaluated on Surface expression of gp90MEL-14 and receptor shedding. Stimulation of lymphocytes with protein kinase C activators results in nearly complete loss of surface expression of gp90MEL-14 within 1 hour due to proteolytic cleavage and receptor shedding.
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