Key result
Chronic atrial fibrillation increases miR-21 expression in human atrial myocytes, decreasing L-type Ca2+ current density by downregulating calcium channel subunits.
Why the study?
Does chronic atrial fibrillation increase miR-21 expression and decrease L-type calcium current in human atrial myocytes?
Does chronic atrial fibrillation increase miR-21 expression and decrease L-type calcium current in human atrial myocytes?
Chronic atrial fibrillation increases miR-21 expression, which downregulates L-type calcium channel subunits and decreases calcium current density, contributing to electrical remodeling.
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May support miR-21–mediated electrical remodeling in chronic AF; leaves open therapeutic targeting in humans.
Barana et al. (2014) studied Chronic atrial fibrillation. Chronic atrial fibrillation vs. Sinus rhythm was evaluated on miR-21 expression and L-type Ca(2+) current density. Chronic atrial fibrillation increases miR-21 expression in human atrial myocytes, decreasing L-type Ca2+ current density by downregulating calcium channel subunits.
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