Key result
Mental stress increased T wave amplitude in CAD patients (4 microV) but decreased it in controls (-20 microV) under placebo (P<0.001); nitroglycerine reversed this effect in CAD patients.
Why the study?
Does nitroglycerine improve mental stress-induced ventricular repolarization changes in patients with stable CAD compared to healthy controls?
RCT (n=28)
Does nitroglycerine improve mental stress-induced ventricular repolarization changes in patients with stable CAD compared to healthy controls?
Absolute Event Rate: 4% vs -20%
p-value: p=<0.001
Nitroglycerine normalizes the abnormal ventricular repolarization response to mental stress seen in patients with stable coronary artery disease.
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Nitroglycerine may normalize abnormal repolarization responses to mental stress in stable CAD; leaves open clinical relevance in larger trials.
Taggart et al. (2009) conducted an RCT in Coronary artery disease (n=28). Nitroglycerine (NTG) vs. Placebo was evaluated on Change in T wave amplitude (T(amp)) during mental arithmetic under placebo (p=<0.001). Mental stress increased T wave amplitude in CAD patients (4 microV) but decreased it in controls (-20 microV) under placebo (P<0.001); nitroglycerine reversed this effect in CAD patients.
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