Key result
Non-invasive central aortic pressure assessment provides superior prognostic value for cardiovascular events compared to brachial blood pressure and demonstrates differential responses to various antihypertensive drug classes.
Non-invasive assessment of central aortic pressure provides superior predictive value for cardiovascular events compared to brachial blood pressure and can help guide the selection of antihypertensive therapies.
May aid risk stratification in hypertension; leaves open whether it guides therapy selection in trials.
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be noninvasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.
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Williams et al. (2016) conducted a review in Hypertension and Cardiovascular Disease. Non-invasive central aortic pressure (CAP) assessment vs. Brachial blood pressure measurement was evaluated. Non-invasive central aortic pressure assessment provides superior prognostic value for cardiovascular events compared to brachial blood pressure and demonstrates differential responses to various antihypertensive drug classes.
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