Key result
In dogs, the circulating beta post-distribution half-lives of proANF 1-98 and proANF 31-67 are approximately 45 minutes, whereas the beta half-life of ANF is 10 minutes after right ventricular pacing.
Population
Six male mongrel dogs
Comparison
Right ventricular pacing at 100, 125, 150, and… vs Baseline
Design
Preclinical
Follow-up
206 minutes
Authors
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No immediate clinical implications; leaves open whether longer proANF half-lives offer advantages over ANF in human heart failure.
The post-distribution half-lives of proANF 1-98 and proANF 31-67 are significantly longer (approximately 45 minutes) than that of ANF (10 minutes) following rapid right ventricular pacing in dogs.
Ackerman et al. (1992) studied this question. Right ventricular pacing vs. Baseline was evaluated on Release rate constants and disappearance rate constants for proANF 1-98, proANF 31-67, and ANF. In dogs, the circulating beta post-distribution half-lives of proANF 1-98 and proANF 31-67 are approximately 45 minutes, whereas the beta half-life of ANF is 10 minutes after right ventricular pacing.
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