What question did this study set out to answer?

To determine the circadian variation of prohormone atrial natriuretic peptides in human plasma concentrations.

Circadian Rhythm of Prohormone Atrial Natriuretic Peptides 1-30, 31-67 and 99-126 in Man

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Randomized trial examines plasma concentration variation of atrial natriuretic peptides in men, suggesting rhythmic physiological patterns.

To determine the circadian variation of prohormone atrial natriuretic peptides in human plasma concentrations.
Eight housestaff volunteers, 5 men and 3 women, ages 25-39, were studied over 24 hours.
Blood samples were taken at various times (0800, 1200, 1600, 2000, 0000, 0400, and 0800 next day).
Subjects included participants who remained awake all night and those who slept from midnight to 0800.
All three peptide hormones showed peak levels at 0400 in both supine and upright positions.
Circadian rhythms were confirmed in active individuals regardless of posture.
N-terminal fragments pro ANF 1-30 and 31-67 exhibit similar circadian patterns to ANF.

Winters et al. (1988) studied this question.

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Randomized trial examines plasma concentration variation of atrial natriuretic peptides in men, suggesting rhythmic physiological patterns.