Key result
Atrial natriuretic factor augmented intracellular and extracellular cGMP in renal cells, and urinary cGMP correlated with ANF-induced natriuresis in awake rats.
Why the study?
Does urinary cGMP excretion reflect the renal activity of atrial natriuretic factor in vivo?
Population
Renal epithelial LLC-PK1 cells and awake rats
Design
Preclinical
Authors
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Supports urinary cGMP as ANF activity marker in rat models; leaves open human translation and clinical validation.
Does urinary cGMP excretion reflect the renal activity of atrial natriuretic factor in vivo?
Urinary cGMP excretion correlates with ANF-induced natriuresis and may be a useful biological marker for the renal activity of ANF in vivo.
Wong et al. (1988) studied this question. Atrial natriuretic factor (ANF) was evaluated on Extracellular cGMP accumulation and urinary excretion of cGMP. Atrial natriuretic factor augmented intracellular and extracellular cGMP in renal cells, and urinary cGMP correlated with ANF-induced natriuresis in awake rats.
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