Key result
Early postmenopausal status was not associated with differences in brachial artery flow-mediated dilation compared to late premenopausal status in physically active females (4.7% vs 4.6%; P=0.724).
Why the study?
The benefits of exercise on vascular health are inconsistent in postmenopausal females.
Do blood pressure and markers of vascular function differ between physically active early post- and late premenopausal females?
Cross-Sectional (n=30)
Do blood pressure and markers of vascular function differ between physically active early post- and late premenopausal females?
Absolute Event Rate: 4.7% vs 4.6%
p-value: p=0.724
Blood pressure and markers of vascular function largely do not differ between physically active late pre- and early postmenopausal females, suggesting physical activity may preserve vascular health across the menopausal transition.
Does not support practice changes in vascular monitoring for active women; leaves open whether physical activity preserves function across menopause.
PURPOSE: The benefits of exercise on vascular health are inconsistent in postmenopausal females. We investigated if blood pressure and markers of vascular function differ between physically active early post- and late premenopausal females. METHODS: We performed a cross-sectional comparison of 24-h blood pressure, brachial artery flow-mediated dilation, microvascular reactivity (reactive hyperemia), carotid-femoral pulse wave velocity, and cardiac baroreflex sensitivity between physically active late premenopausal (n = 16, 48 ± 2 yr) and early postmenopausal (n = 14, 53 ± 2 yr) females. RESULTS: Physical activity level was similar between premenopausal (490 ± 214 min·wk-1) and postmenopausal (550 ± 303 min·wk-1) females (P = 0.868). Brachial artery flow-mediated dilation (pre, 4.6 ± 3.9, vs post, 4.7% ± 2.2%; P = 0.724), 24-h systolic (+5 mm Hg, 95% confidence interval [CI] = -1 to +10, P = 0.972) and diastolic (+4 mm Hg, 95% CI = -1 to +9, P = 0.655) blood pressures, total reactive hyperemia (pre, 1.2 ± 0.5, vs post, 1.0 ± 0.5 mL·mm Hg-1; P = 0.479), carotid-femoral pulse wave velocity (pre, 7.9 ± 1.7, vs post, 8.1 ± 1.8 m·s-1; P = 0.477), and cardiac baroreflex sensitivity (-8 ms·mm Hg-1, 95% CI = -20.55 to 4.62, P = 0.249) did not differ between groups. By contrast, peak reactive hyperemia (-0.36 mL·min-1⋅mm Hg-1, 95% CI = -0.87 to +0.15, P = 0.009) was lower in postmenopausal females. CONCLUSIONS: These results suggest that blood pressure and markers of vascular function do not differ between physically active late pre- and early postmenopausal females.
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Debray et al. (2022) conducted a cross-sectional in Physically active females (n=30). Early postmenopausal status vs. Late premenopausal status was evaluated on Brachial artery flow-mediated dilation (p=0.724). Early postmenopausal status was not associated with differences in brachial artery flow-mediated dilation compared to late premenopausal status in physically active females (4.7% vs 4.6%; P=0.724).
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