What question did this study set out to answer?

This research aims to uncover how genetic variations in MHC molecules influence T cell responses and peptide binding.

The molecular basis of class II MHC allelic control of T cell responses

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Randomized trial identifies molecular mechanisms affecting T cell responses via MHC polymorphism, suggesting significant immunological implications.

This research aims to uncover how genetic variations in MHC molecules influence T cell responses and peptide binding.
Functional T cell response testing combined with peptide binding measurements on transfected cells.
Study of specific polymorphic residues in the E alpha E beta dimer affecting peptide presentation.
Comparison of T cell responses to different cytochrome peptides presented by distinct MHC molecules.
Replacement of valine with glutamic acid at beta 29 affects pigeon peptide binding, indicating quantitative control of binding.
Changes in binding parallel T cell responses, revealing a correlation between molecular structure and immune response.
Conformational changes in peptide binding due to polymorphic residues modify T cell responses, even without direct contact.

Racioppi et al. (1991) studied this question.

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Randomized trial identifies molecular mechanisms affecting T cell responses via MHC polymorphism, suggesting significant immunological implications.