What question did this study set out to answer?

This research aims to explore the roles of Akt and Pim kinases in regulating cell survival and potential therapeutic implications.

October 1, 2005Journal of Clinical Investigation402 citationsOpen Access

The survival kinases Akt and Pim as potential pharmacological targets

RARavi K. Amaravadi

Key Points

This research aims to explore the roles of Akt and Pim kinases in regulating cell survival and potential therapeutic implications.
Examined the mechanisms of Akt and Pim kinase activation.
Analyzed their roles in apoptosis and cellular metabolism.
Discussed pharmacological strategies targeting these kinases.
Akt and Pim kinases regulate cell survival through overlapping pathways.
Pharmacological targeting of these kinases could benefit treatments for cancer and inflammatory diseases.

Abstract

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.

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