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SUMMARY A previously unreported coronavirus-like agent was detected in diarrheal fecal material obtained from neonatal calves in 19 herds from western Nebraska. Techniques for purification and the electron microscopic morphologic features of the coronavirus-like agent are described. Gnotobiotic, colostrum-deprived, and colostrum-fed neonatal calves were experimentally inoculated with coronavirus-like agent, and diarrhea was produced in all calves. Coronavirus-like agent was seen in the feces of each of the experimentally inoculated calves when diarrheal fecal samples were fractionated, and the fractions were examined by electron microscopy.
Stair et al. (1972) studied this question.