Key result
In pigs, intermittent positive pressure ventilation with increasing PEEP decreased cardiac output by up to 66%, causing blood flow redistribution to preserve vital organs.
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High PEEP may compromise cardiac output during ventilation; leaves open optimal strategies for organ perfusion in humans.
Haldén et al. (1982) studied this question. Intermittent positive pressure ventilation with PEEP vs. Spontaneous breathing was evaluated on Cardiac output and blood flow distribution. In pigs, intermittent positive pressure ventilation with increasing PEEP decreased cardiac output by up to 66%, causing blood flow redistribution to preserve vital organs.
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