Key result
Increases in pretest conduction time shift AA and HA curves in opposite directions, but when corrected, both curves display similar rate-dependent AV nodal function.
Population
12 rabbit heart preparations (6 for S1S2S3 protocols, 6 for frequency step protocols)
Design
Preclinical
Authors
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Accounting for pretest conduction time may refine AV nodal assessments; animal data leave open clinical translation.
Increases in pretest conduction time play a pivotal role in apparent recovery-index-dependent differences in rate-dependent AV nodal function by shifting AA and HA curves in opposite directions.
Tadros et al. (2007) studied AV nodal function assessment (n=12). Variation of basic, pretest, and test cycle lengths vs. Control was evaluated on Nodal responses as AA and HA curves. Increases in pretest conduction time shift AA and HA curves in opposite directions, but when corrected, both curves display similar rate-dependent AV nodal function.
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