Key result
In isolated rabbit hearts, beat-to-beat increases in facilitation broadened the range of recovery times for successful conduction, while fatigue prolonged NCT, ERPN, and FRPN equally for each beat.
This preclinical study elucidates the complementary roles of recovery time, facilitation, and fatigue in generating Wenckebach periodicity in the AV node.
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Caution against clinical extrapolation from rabbit hearts; leaves open human translation of facilitation and fatigue in AV nodal Wenckebach.
Zhao et al. (1992) studied Wenckebach periodicity. Premature stimulation protocols was evaluated on Beat-to-beat changes in nodal conduction time (NCT) and effective (ERPN) and functional refractory periods of node (FRPN). In isolated rabbit hearts, beat-to-beat increases in facilitation broadened the range of recovery times for successful conduction, while fatigue prolonged NCT, ERPN, and FRPN equally for each beat.
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