Key result
Treatment with a thiazide diuretic does not significantly affect blood pressure variability compared to placebo, as the coefficient of variation of systolic and diastolic blood pressure did not differ at end of treatment.
Why the study?
Do thiazide diuretics affect blood pressure variability in adult patients with primary hypertension?
Population
33,611 adult patients with primary hypertension from double-blind randomized controlled trials included in…
Comparison
Thiazide diuretics vs Placebo or untreated controls
Design
Meta-analysis, Double blind randomized controlled trials, Double blind
Follow-up
3-12 weeks (Review 1) and at least 1 year (Review 2)
Authors
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Thiazides need not be prioritized to target blood pressure variability; confirms no effect on coefficient of variation versus placebo.
Systematic Review (n=33,611)
Do thiazide diuretics affect blood pressure variability in adult patients with primary hypertension?
Absolute Event Rate: 9.9% vs 9.4%
p-value: p=not significant
Thiazide diuretics do not significantly affect blood pressure variability, and using specific blood pressure thresholds for trial entry artificially reduces baseline variability.
Musini et al. (2009) conducted a systematic review in Primary hypertension (n=33,611). Thiazide diuretics vs. Placebo or untreated controls was evaluated on Coefficient of variation of systolic blood pressure at end of treatment (p=not significant). Treatment with a thiazide diuretic does not significantly affect blood pressure variability compared to placebo, as the coefficient of variation of systolic and diastolic blood pressure did not differ at end of treatment.
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