Key result
Regional acute ischaemia and afterload elevations attenuated, entirely lost, or reversed normal intraventricular pressure gradients in the left ventricle of rabbits.
Population
Open-chest anaesthetized rabbits (n=6)
Comparison
Regional acute ischaemia and afterload elevations vs Basal conditions
Design
Preclinical
Authors
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IVPG attenuation in ischaemia may signal LV dysfunction; rabbit data leave open human translation.
Intraventricular pressure gradients, markers of normal left ventricular function related to physiological asynchrony, are attenuated or lost during acute regional ischaemia and increased afterload.
Guerra et al. (2012) studied Myocardial ischaemia and ventricular afterload (n=6). Ischaemia and afterload elevation vs. Basal conditions was evaluated on Intraventricular pressure gradients (IVPGs). Regional acute ischaemia and afterload elevations attenuated, entirely lost, or reversed normal intraventricular pressure gradients in the left ventricle of rabbits.
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