Key result
A new isovolumic analytical model of the canine left ventricle yields ventricular elastance independently from circulation properties, making it insensitive to preload and afterload.
A new analytical model of the canine left ventricle allows for the determination of ventricular elastance independently of preload and afterload.
May refine load-independent elastance assessment in animal models; leaves open human validation and clinical translation.
The mathematical reason for wide discrepancies in previous time-varying elastance or compliance based models of the ventricle is presented. The fundamental difficulty of describing the mechanical properties of the ventricle with an elastance function that is set a priori, and the practical problem of the act of measurement changing the compliance magnitude are described. A new, isovolumic analytical model of the canine left ventricle yields ventricular elastance from the classic definition relating ventricular pressure and volume: E/sub /spl nu//=/spl part/p/sub /spl nu////spl part/V/sub /spl nu//. This new ventricle model is defined independently from circulation properties, allowing separation of source (ventricle) effects from load (circulation) effects. Elastance determined in this way is insensitive to ventricular preload and afterload.
No takes yet. Share an insight, caveat, or question.
Palladino et al. (2002) studied Ventricular elastance. Isovolumic analytical model of the canine left ventricle vs. Previous time-varying elastance or compliance based models was evaluated on Ventricular elastance. A new isovolumic analytical model of the canine left ventricle yields ventricular elastance independently from circulation properties, making it insensitive to preload and afterload.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: