Key result
A new ventricle model based on a volume and time dependent isovolumic pressure function eliminates the inability to separate source and load seen in traditional time-varying elastance descriptions.
A new analytical ventricle model based on a volume and time dependent isovolumic pressure function allows for the separation of source and load, overcoming limitations of traditional time-varying elastance models.
May advance ventricular modeling by separating source and load; leaves open human validation and clinical translation.
Analytical models of the cardiovascular system typically use time-varying elastance descriptions of the heart chambers, e.g. the left ventricle. These elastance functions are derived from volume and pressure data. Consequently, although they are used to characterize the ventricle alone, their origin makes them characteristic of a particular ventricle and arterial load combination. This inability to separate source and load is eliminated by a new ventricle model based on a volume and time dependent isovolumic pressure function, derived from animal experiments.
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Palladino et al. (2002) studied Cardiovascular system modeling. New ventricle model based on a volume and time dependent isovolumic pressure function vs. Time-varying elastance descriptions was evaluated on Separation of source and load. A new ventricle model based on a volume and time dependent isovolumic pressure function eliminates the inability to separate source and load seen in traditional time-varying elastance descriptions.
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