Key result
Genetic analysis of diverse populations revealed that at least 2 major intragenic sites and 1 minor promoter site in the ACE gene are associated with circulating ACE levels via additive effects.
Observational
Yes
The study highlights the importance of analyzing diverse populations to identify specific quantitative trait nucleotides influencing ACE plasma concentration.
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Associations with ACE levels should not guide therapy; extends haplotype mapping to diverse populations but leaves clinical relevance open.
Roger Cox (2002) conducted an observational in Circulating angiotensin-1-converting enzyme (ACE) concentration. ACE gene variants and haplotypes vs. Alternative allelic combinations was evaluated on Association of genetic variants with the ACE quantitative trait. Genetic analysis of diverse populations revealed that at least 2 major intragenic sites and 1 minor promoter site in the ACE gene are associated with circulating ACE levels via additive effects.
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