Deletion of alternative exon 33 of the CaV1.2 calcium channel in mice enhanced long-term potentiation and abolished long-term depression, while impairing associative learning and social behaviors.
Deletion of exon 33 in the CaV1.2 channel alters synaptic plasticity and impairs cognitive and social behaviors in mice, providing a link to psychiatric disorder phenotypes.
Abstract The CACNA1C (calcium voltage-gated channel subunit alpha 1 C) gene that encodes the Ca V 1.2 channel is a prominent risk gene for neuropsychiatric and neurodegenerative disorders with cognitive and social impairments like schizophrenia, bipolar disorders, depression and autistic spectrum disorders (ASD). We have shown previously that mice with exon 33 deleted from Ca V 1.2 channel (Ca V 1.2-exon 33 −/− ) displayed increased Ca V 1.2 current density and single channel open probability in cardiomyocytes, and were prone to develop arrhythmia. As Ca 2+ entry through Ca V 1.2 channels activates gene transcription in response to synaptic activity, we were intrigued to explore the possible role of Cav1.2 Δ 33 channels in synaptic plasticity and behaviour. Homozygous deletion of alternative exon 33 resulted in enhanced long-term potentiation (LTP), and lack of long- term depression (LTD), which did not correlate with enhanced learning. Exon 33 deletion also led to a decrease in social dominance, sociability and social novelty. Our findings shed light on the effect of gain-of-function of Ca V 1.2 Δ 33 signalling on synaptic plasticity and behaviour and provides evidence for a link between Ca V 1.2 and distinct cognitive and social behaviours associated with phenotypic features of psychiatric disorders like schizophrenia, bipolar disorder and ASD.
Navakkode et al. (Mon,) reported a other. CaV1.2-exon 33 deletion vs. Wild-type mice was evaluated on Synaptic plasticity (LTP/LTD) and associative memory. Deletion of alternative exon 33 of the CaV1.2 calcium channel in mice enhanced long-term potentiation and abolished long-term depression, while impairing associative learning and social behaviors.