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Strains of Staphylococcus aureus possessing large amounts of protein A tended to resist phagocytosis more than strains that contain lesser amounts or none of this protein. Protein A extracted from S. aureus inhibited phagocytosis of both S. aureus and Escherichia coli in in vitro phagocytosis systems. The antiphagocytic effect was produced by nonspecific reaction of protein A with the Fc piece of γG globulin.
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Dossett et al. (1969) studied this question.
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