Key result
Mitral stenosis was associated with a significantly higher mitral valve opening velocity (536 vs 293 mm/sec) and shorter duration (23 vs 45 msec) compared to normal subjects (P<0.001).
Why the study?
Do early diastolic cardiac events measured by noninvasive recordings differ between normal subjects and patients with mitral stenosis?
Observational (n=96)
Do early diastolic cardiac events measured by noninvasive recordings differ between normal subjects and patients with mitral stenosis?
Absolute Event Rate: 536% vs 293%
p-value: p=<0.001
Mitral valve opening motion velocity is significantly higher and duration shorter in patients with mitral stenosis compared to normal subjects, while isovolumic relaxation time remains similar.
Cardiac events of early diastole were studied in 50 normal subjects and 46 patients with mitral stenosis (MS) by simultaneous recordings of the mitral valve echogram (MVE), phonocardiogram, and apexcardiogram (ACG). Left ventricular isovolumic relaxation time (IRT), measured between A2 and onset of the MVE opening motion, had almost the same values in normals 54 +/- 7 msec, and MS 51 +/- 16 msec. The interval between A2 and the ACG "O" point was approximately double that of IRT: 99 +/- 11 msec in normal subjects, 109 +/- 20 msec in MS. The normal MVE opening motion had a velocity 293 +/- 76 mm/sec and duration 45 +/- 6 msec, values significantly different (P less than 0.001) from 536 +/- 271 mm/sec, 23 +/- 7.5 msec found in MS patients. In atrial fibrillation the length of the cardiac cycle did not affect A2-O interval or mitral valve opening movement duration; however cycle length was clearly related to isovolumic relaxation time. This resulted in a variation in the interval between completion of the mitral valve opening (opening snap) and O point. This interval was longer after a short diastole and vice versa.
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Toutouzas et al. (1978) conducted an observational in Mitral stenosis (n=96). Mitral stenosis vs. Normal subjects was evaluated on Mitral valve echogram opening motion velocity (mm/sec) (p=<0.001). Mitral stenosis was associated with a significantly higher mitral valve opening velocity (536 vs 293 mm/sec) and shorter duration (23 vs 45 msec) compared to normal subjects (P<0.001).
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