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June 6, 2026Frontiers in OncologyOpen Access

Proximal vs. total gastrectomy for proximal advanced gastric cancer after neoadjuvant chemotherapy: a systematic review and meta-analysis of propensity score-matched studies

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Authors

YLYueping LiQingdao UniversityXNXiaofei NieQingdao UniversityZLZhang LiandaQingdao University

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Implication

Systematic review compares outcomes after proximal and total gastrectomy in gastric cancer, suggesting similar long-term results.

Key Points

  • This analysis aims to compare outcomes between proximal and total gastrectomy in patients with proximal advanced gastric cancer after undergoing neoadjuvant chemotherapy.
  • Systematically searched major databases for studies comparing outcomes of PG and TG.
  • Included four propensity score-matched comparative studies with a total of 589 patients.
  • Analyzed overall survival, recurrence-free survival, postoperative complications, and lymph node metastasis patterns.
  • Operative time was shorter for PG (MD -21.4 min, 95% CI -23.7 to -19.1) with slightly greater blood loss (MD 8.9 mL, 95% CI 4.9-12.8).
  • No significant differences in overall postoperative complications (OR 1.05, 95% CI 0.71-1.54) or long-term survival rates (HR 1.23, 95% CI 0.83-1.84).
  • Proximal gastrectomy offers comparable long-term outcomes to total gastrectomy without added morbidity.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a23b80771a5da9775e7461ehttps://doi.org/10.3389/fonc.2026.1805000
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Also Consider

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  1. 1Long-Term Outcome of Proximal Gastrectomy for Upper-Third Advanced Gastric and Siewert Type II Esophagogastric Junction Cancer Compared With Total Gastrectomy: A Propensity Score-Matched Analysis2024 · 13 citations
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  3. 3PRODIGY: A Phase III Study of Neoadjuvant Docetaxel, Oxaliplatin, and S-1 Plus Surgery and Adjuvant S-1 Versus Surgery and Adjuvant S-1 for Resectable Advanced Gastric Cancer2021 · 375 citations
  4. 4Total versus proximal gastrectomy for proximal gastric cancer after neoadjuvant chemotherapy: a multicenter retrospective propensity score-matched cohort study2023 · 21 citations