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This review aims to characterize the clinical features and outcomes of hypoglossal nerve palsy due to internal carotid artery dissection.

June 6, 2026Frontiers in NeurologyOpen Access

Clinical characteristics of hypoglossal nerve palsy secondary to internal carotid artery dissection: a systematic review and illustrative case

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Systematic review characterizes hypoglossal nerve palsy due to carotid artery dissection, highlighting diagnostic and treatment implications.

This review aims to characterize the clinical features and outcomes of hypoglossal nerve palsy due to internal carotid artery dissection.
Systematic review following PRISMA 2020 guidelines, registered in PROSPERO (CRD420251141162).
Databases searched include PubMed, Scopus, Web of Science, and Embase for studies on adults with hypoglossal nerve palsy due to internal carotid artery dissection.
Clinical data, imaging findings, treatments, and outcomes were extracted and analyzed descriptively.
Included 73 studies with 87 patients, mean age 48.5 years, 86.2% male.
Isolated hypoglossal nerve palsy occurred in 64.3% of cases; diagnostic error noted in 31.0%, leading to delayed management.
Favorable outcomes achieved in 65.6% of patients; 10.3% underwent surgical or endovascular treatment.

Kang et al. (2026) studied this question.

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Systematic review characterizes hypoglossal nerve palsy due to carotid artery dissection, highlighting diagnostic and treatment implications.