A case report of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with literature review

Objective This paper aims to systematically investigate the clinical and pathological characteristics of TL-LGNPPA and its differential diagnosis, with the objective of enhancing our understanding of this tumor and facilitating the development of more precise treatment strategies. Methods A systematic review and meta-analysis of the clinical and pathological features, as well as differential diagnosis, of a case of TL-LGNPPA were conducted, and a comprehensive literature review was conducted by analyzing relevant articles published on PubMed. Results The histological features of TL-LGNPPA are typically characterized by typical papillary and ductal structures, with fibrovascular axis present in the interstitium. Focal nuclear grooves may occasionally be seen, with moderate degree of atypia. Immunohistochemical analysis showed that all tumors expressed TTF-1 and CK, but TG was mostly negative, and the Ki-67 proliferation index was generally less than 10% in most cases. Conclusions TL-LGNPPA is a rare nasopharyngeal tumor with histological features similar to papillary thyroid carcinoma. An accurate diagnosis requires a comprehensive consideration of histological morphological assessment, immunohistochemical analysis and imaging examination.