What does this research mean for the field?

Alzheimer's disease patients exhibit reduced HIF1A and HIF1AN gene expression in peripheral blood mononuclear cells, which correlates with altered inflammatory markers and suggests HIF-1 pathway dysregulation is linked to neuroinflammation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to assess the role of HIF-1 and its regulators in blood cells of older Alzheimer’s disease patients.

June 6, 2026Frontiers in Aging NeuroscienceOpen Access

Unraveling the role of HIF-1 in peripheral blood mononuclear cells from older patients with Alzheimer’s disease

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Authors

BABeatrice ArosioUniversity of Milan EFEvelyn FerriFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico PRPaolo Dionigi RossiFaculdade São Leopoldo Mandic

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Implication

Randomized trial evaluates HIF-1 pathway in Alzheimer's patients, suggesting neuroinflammation links.

Key Points

This research aims to assess the role of HIF-1 and its regulators in blood cells of older Alzheimer’s disease patients.
Evaluated gene expression of HIF1A and HIF1AN in PBMCs from 83 AD patients and 308 controls.
Analyzed associations with inflammatory genes and protein concentrations in plasma.
AD patients had lower HIF1A and HIF1AN expression compared to controls, linked to higher odds of AD.
HIF1A expression positively correlated with IL-6, IL-10, TNF-α, IL-1B, and TREM-1 gene expression.
HIF1AN expression negatively correlated with IL-6, IL-1B, and TREM-1 expression, and lower IL-10 concentrations.

Cite This Study

Arosio et al. (2026) studied this question.

synapsesocial.com/papers/6a23b96a71a5da9775e754e8 https://doi.org/10.3389/fnagi.2026.1831919

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Unraveling the role of HIF-1 in peripheral blood mononuclear cells from older patients with Alzheimer’s disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Unraveling the role of HIF-1 in peripheral blood mononuclear cells from older patients with Alzheimer’s disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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