Demonstrates a new method for creating phosphacoumarins, suggesting a modular synthesis approach.
A Pd-catalyzed addition/cyclization cascade of di- and trialkynylphosphine oxides with (2-hydroxyaryl)boronic acids affords phosphacoumarins bearing P–C(sp), P–C(sp2), or P–C(sp3) linkages in high yields. The reaction proceeds via an unconventional P–C/O exchange in which an alkynyl group serves as the leaving group and the alkyne acts as both the addition site and the leaving group. This single-scaffold approach to three distinct P–C bond types is attractive for the modular synthesis of phosphorus heterocycles.
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Zhu et al. (2026) studied this question.
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