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June 6, 2026Frontiers in MedicineOpen Access

COVID-19 vaccination in pregnancy: efficacy of second-generation vaccines, maternal-neonatal safety, and strategies to address vaccine hesitancy

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Authors

JXJia XuGansu University of Traditional Chinese MedicineFLFang LiuGansu University of Traditional Chinese MedicineHYHan-Ying YuanGansu University of Traditional Chinese Medicine

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Overview

Review evaluates second-generation COVID-19 vaccination efficacy and safety in pregnant women, addressing barriers and strategies for improved uptake.

Key Points

  • This review aims to evaluate the efficacy and safety of second-generation COVID-19 vaccines in pregnant women and to analyze barriers to vaccination.
  • Review of current vaccination strategies for pregnant women using second-generation COVID-19 vaccines.
  • Analysis of maternal and neonatal health outcomes.
  • Examination of barriers to vaccine uptake among pregnant women.
  • Confirmed efficacy and safety of second-generation COVID-19 vaccines in pregnant women.
  • Elevated maternal risk for severe disease linked to SARS-CoV-2 infection during pregnancy.
  • Identified significant vaccine hesitancy due to concerns over adverse effects and fetal safety.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a23b96a71a5da9775e754f8https://doi.org/10.3389/fmed.2026.1835847
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