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June 6, 2026Food FrontiersOpen Access

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum , Against Aspergillus fumigatus : Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

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Authors

ABAcharya BalkrishnaLGLovely GuptaRSRani Singh

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Overview

Randomized trial demonstrates antifungal effects of cumin against Aspergillus fumigatus, suggesting a dual treatment approach for resistance.

Key Points

  • To investigate the antifungal activity of cumin seed oil against pathogenic Aspergillus fumigatus and the underlying mechanisms.
  • Used supercritical-fluid extraction for cumin oil extraction (CcSO).
  • Conducted chemical profiling with GC-MS/MS and tested antifungal effects at concentrations of 0.7–1.5 mg/mL.
  • Evaluated effects on fungal biomass, gene expression, biofilm formation, and morphological changes in Aspergillus fumigatus.
  • CcSO significantly suppressed fungal biomass and melanin production, downregulating PksP, Erg1, Erg4, Erg6, and SrbA genes.
  • Impaired hyphal growth and delayed germination were observed in treated Aspergillus fumigatus, with visible deformations.
  • CcSO eradicated pre-formed biofilms and prevented further biofilm formation, indicating its fungicidal properties.

Cite This Study

Balkrishna et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ac71a5da9775e757c0https://doi.org/10.1002/fft2.70309
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