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June 6, 2026Intensive Care Medicine ExperimentalOpen Access

Chest compression synchronized ventilation versus chest compression superimposed by sustained inflation in asphyxiated newborn piglets: a randomized animal trial

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Authors

RHRaza HyderiSPShrieya PraveenMOMegan O’Reilly

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Overview

Randomized trial compares outcomes of synchronized ventilation and sustained inflation in asphyxiated newborn piglets, indicating similar effects.

Key Points

  • This research compares the effectiveness of two resuscitation techniques for asphyxiated newborn piglets: chest compressions with synchronized ventilation and sustained inflation.
  • Randomized trial with newborn piglets (n=16), assigning to either synchronized ventilation or sustained inflation during resuscitation.
  • Piglets were anesthetized, intubated and exposed to a 45-min hypoxia phase followed by asphyxia and cardiac arrest.
  • Hemodynamic and respiratory parameters were continuously monitored after resuscitation.
  • Time to return of spontaneous circulation (ROSC) was 68 seconds for synchronized ventilation vs. 71 seconds for sustained inflation, p=0.537.
  • ROSC rates were 75% for synchronized ventilation compared to 63% for sustained inflation, p=1.000.
  • Synchronized ventilation had higher peak inflation pressure (45 cmH2O) and lower positive end-expiratory pressure (5.3 cmH2O) compared to sustained inflation, both p<0.001.

Cite This Study

Hyderi et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9f271a5da9775e75b21https://doi.org/10.1186/s40635-026-00920-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiopulmonary resuscitation with Synchronized Ventilation versus 3:1 Compression to Ventilation ratio in a neonatal porcine model2026
  2. 2Cardiopulmonary resuscitation with Synchronized Ventilation: A new technique of Neonatal Resuscitation that reduces time to return of spontaneous circulation in a neonatal porcine model2025
  3. 3Chest Compression superimposed with Sustained Inflation – Translating preclinical findings into a neonatal clinical trial2026
  4. 4Continuous Chest Compressions with Asynchronous Ventilation in Asphyxiated Preterm Lambs with Asystole2025
  5. 51363: MECHANICAL VENTILATION MODES IN SWINE PEDIATRIC HYPOXIA CARDIAC ARREST MODEL: PILOT STUDY2026