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June 6, 2026BMC GastroenterologyOpen Access

Association of red blood cell distribution width to albumin ratio with all-cause and cardiovascular mortality among adults with MASLD

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Authors

ZNZe-Bin NiLHLian-Zhen HuangQYQi-Rong Yao

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Overview

Randomized trial evaluates RAR's association with mortality in adults with MASLD, indicating its potential as a prognostic tool.

Key Points

  • This study aims to evaluate the relationship between the red blood cell distribution width to albumin ratio and mortality outcomes in adults diagnosed with metabolic dysfunction-associated steatotic liver disease.
  • Data analyzed from the National Health and Nutrition Examination Survey 1999–2018
  • Participants categorized into RAR quartiles
  • Weighted Cox proportional hazards and Fine-Gray competing risk models used for analysis.
  • Individuals in the highest RAR quartile experienced a 141% increase in all-cause mortality (HR = 2.41, 95% CI = 1.87–3.10, P < 0.001) compared to the lowest quartile.
  • A 130% increase in cardiovascular mortality was observed with the highest RAR quartile (HR = 3.39, 95% CI = 2.17–5.31, P < 0.001).
  • Each unit increase in RAR correlated with a 93% and 130% increase in all-cause and cardiovascular mortality, respectively (HRs = 1.93 and 2.30, both P < 0.001).

Cite This Study

Ni et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9f271a5da9775e75c07https://doi.org/10.1186/s12876-026-04987-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between the red blood cell distribution width to albumin ratio and cardiovascular outcomes in MASLD patients: a national cohort study integrating machine learning2026
  2. 2Nonlinear association between the erythrocyte distribution width-to-albumin ratio and mortality in older adults: A retrospective cohort study using NHANES 1999 to 2018 data.2026
  3. 3Association of the RDW-to-albumin ratio with MAFLD and hepatic fibrosis in the U.S. population: a national cross-sectional study2026
  4. 4Ratio of Red Blood Cell Distribution Width to Albumin Level and Risk of Mortality2024 · 140 citations
  5. 5Red Cell Distribution Width as an Independent Prognostic Biomarker in MASLD2026