(802) SHIELD: A Multidisciplinary Strategy for Prevention and Treatment of HPV and Associated Cancers

Introduction Human Papillomavirus (HPV) represents one of the most prevalent sexually transmitted infections worldwide, affecting an estimated 85–90% of sexually active individuals. Beyond its somatic consequences, an HPV diagnosis and its associated treatments can lead to considerable psychological distress, including anxiety, depression, fear of social stigma, sexual dysfunction, and disturbances in body image, which can negatively impact emotional well-being, sexual health, intimate relationships, and overall quality of life (Linnehan & Groce, 2000). Despite the documented psychosocial burden associated with HPV, such dimensions remain insufficiently addressed and HPV-related infections and malignancies continue to constitute a significant global public health concern, underscoring the need for further interdisciplinary research and intervention (Baker et al., 2020). This project proposes a comprehensive and multidisciplinary approach integrating innovative diagnostic tools, psychological care, and health education for effective HPV prevention and management. Objective Based on a multidisciplinary approach, SHIELD aims to investigate biopsychosocial risk/protective factors in the development of HPV and associated cancers and to evaluate predictors of psychosexual adjustment to treatment. It also aims to develop and implement a digital intervention program to promote psychological and sexual health and quality of life of people with HPV and related cancers. Methods This project employs a multidisciplinary approach, integrating evidence-based knowledge from psychological, medical, and microbiological sciences, as well as technological innovation. After ethical approval, participants diagnosed with HPV (N=200) will be recruited at a medical center and invited to participate in the study. Biological samples will be collected to unveil relevant genetic variations associated with pre-malignant and malignant HPV-related lesions (WP1). Using a longitudinal design, including a laboratory component with electroencephalography, biopsychosocial protective/risk factors for the development of HPV infections and predictors of individuals' psychosocial and sexual adjustment to treatments will be assessed (WP2). Finally, an e-health self-care tool will be developed and tested for its usability, feasibility, and preliminary effectiveness in promoting overall health, psychological well-being, and sexual well-being, as well as quality of life, among users. Results This project aims to generate knowledge about the predictors of psychosocial and sexual adjustment among individuals undergoing treatment for HPV, while also contributing to increased health literacy and the enhancement of emotional, sexual, and overall quality of life among affected patients. Expected outcomes also include the development of a new diagnostic tool and evidence-based intervention strategies to support patients’ emotional and sexual well-being, and the promotion of more informed, communicative, and patient-centered healthcare practices. Ultimately, the project seeks to foster improved quality of care and to reduce the psychosocial burden associated with HPV and its related conditions. Conclusions Overall, this project is aimed at combating HPV cancers (prevention and treatment) and improving general health, sexual and mental health and wellbeing, health literacy, and quality of life, contributing, ultimately, to enhancing patients’ adherence to medical treatments and ensuring effective disease management. Disclosure No