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This study investigates the relationship between metabolic syndrome severity and the risk of developing erectile dysfunction.

(749) Association Between Metabolic Syndrome Severity and Incident Erectile Dysfunction: A Retrospective Cohort Analysis Using a National Health Database

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This study investigates the relationship between metabolic syndrome severity and the risk of developing erectile dysfunction.
Retrospective cohort analysis using electronic health records from 2015 to 2025.
Included men aged 40-70 with no prior erectile dysfunction, utilizing a validated continuous MetS-Z score.
Cox proportional hazards regression models were used to calculate hazard ratios, adjusting for potential confounders.
Among 48,615 men, 5,128 developed erectile dysfunction during a median follow-up of 7.5 years.
Each standard deviation increase in MetS score was linked to an 18% rise in ED risk (adjusted HR 1.18, 95% CI 1.14–1.22, p < 0.001).
Higher quartiles of MetS score significantly correlated with increased ED risk, reaching an HR of 2.41 for the highest quartile (95% CI 2.23–2.60, p for trend < 0.001).

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Retrospective cohort analysis reveals a dose-response relationship between metabolic syndrome severity and erectile dysfunction risk in men.

Yue et al. (2026) studied this question.

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Retrospective cohort analysis reveals a dose-response relationship between metabolic syndrome severity and erectile dysfunction risk in men.