Multiparametric whole-body magnetic resonance imaging in breast cancer management: A prospective study

Multiparametric Whole-Body Magnetic Resonance Imaging (WB-MRI) may enhance bone metastasis detection in metastatic breast cancer (mBC) patients. We report preliminary results from a prospective clinical trial investigating WB-MRI utility in BC patients with bone-predominant lesions, equivocal imaging findings or oligometastatic disease (OMD). Fifty-nine consecutive patients underwent baseline staging with standard imaging techniques (SIT), followed by WB-MRI. WB-MRI led to treatment-plan modifications in 40% of cases; 83% of lobular carcinoma cases exhibited additional metastases on WB-MRI. Among the 23 patients who underwent at least one reassessment by WB-MRI and SIT, the concordance rate was 69.6%. Among 18 OMD patients, WB-MRI led to the redefinition of the disease status in 44.4% of cases. These findings underscore the value of WB-MRI in BC.