Abstract Introduction Erectile dysfunction (ED) shares common metabolic pathways with cardiovascular and endocrine diseases. Traditional obesity indices such as body mass index (BMI) may not adequately reflect the impact of visceral adiposity on erectile function. Novel indices, including the lipid accumulation product (LAP), relative fat mass (RFM), and body composition–based parameters, may better capture this association. Objective To determine the predictive value of anthropometric and lipid-based indices for ED and to analyze their correlations with erectile function severity. Methods This cross-sectional study included 240 men evaluated for sexual function using the International Index of Erectile Function-5 (IIEF-5). Participants were divided into ED (n = 163, 67.9%) and non-ED (n = 77, 32.1%) groups. Anthropometric and biochemical parameters were collected, and body composition indices were computed (BMI, Ponderal Index, Relative Fat Mass RFM, Body Fat Percentage BFP, and LAP). Logistic regression analyses identified independent predictors of ED and severe ED. Correlations between IIEF-5 and each index were evaluated using Pearson’s test. Results Patients with erectile dysfunction (ED) demonstrated significantly higher rates of metabolic and anthropometric abnormalities compared to men without ED. Waist circumference was markedly greater in the ED group (1.05 ± 0.11 m vs. 0.96 ± 0.11 m, p 0.001), reflecting increased central adiposity. Biochemical evaluation revealed higher fasting glucose (103.0 ± 13.8 vs. 94.9 ± 11.2 mg/dL, p 0.001) and triglyceride levels (180.3 ± 56.8 vs. 149.9 ± 57.8 mg/dL, p 0.001) in the ED group. (Table-1) Regarding body composition indices, Relative Fat Mass (RFM) and Lipid Accumulation Product (LAP) were significantly elevated in ED patients (RFM: 30.6 ± 4.0 vs. 27.1 ± 4.5, p 0.001; LAP: 83.9 ± 38.6 vs. 50.4 ± 23.7, p 0.001). Body Fat Percentage (BFP) and Body Mass Index (BMI) did not differ significantly, although both showed higher mean values in men with ED. In multivariate logistic regression, LAP remained the only independent predictor of both overall ED (OR = 1.03, 95% CI 1.01–1.04, p 0.001) and severe ED (OR = 1.03, 95% CI 1.01–1.05, p = 0.012). (Table-2 and 3) Correlation analysis demonstrated a strong inverse relationship between erectile function (IIEF-5 scores) and metabolic indices: LAP (r = –0.71, p 0.001), RFM (r = –0.68, p 0.001), BFP (r = –0.63, p 0.001), and BMI (r = –0.59, p 0.001). (Figure 1) ROC analyses confirmed the high discriminative performance of LAP for both overall and severe ED (AUC = 0.85 and 0.82, respectively). (Figures 2 and 3) Conclusions Lipid Accumulation Product (LAP) showed the strongest inverse correlation with erectile function and remained an independent predictor of both overall and severe ED. Body composition indices such as RFM and BFP were also significantly correlated but not independently predictive after adjustment. LAP, a simple marker derived from waist circumference and triglyceride levels, may serve as a practical, noninvasive indicator of metabolic risk underlying ED. Disclosure No
Gul et al. (Mon,) studied this question.