What question did this study set out to answer?

To assess the impact of implementing two-stage testing for Clostridioides difficile infections in a veterans hospital.

June 6, 2026Open Access

Implementation of two-stage testing for Clostridioides difficile at a tertiary referral veterans hospital

Key Points

To assess the impact of implementing two-stage testing for Clostridioides difficile infections in a veterans hospital.
Adoption of two-stage testing involving PCR followed by toxin testing for confirmatory results.
Conducted at a tertiary Veterans Affairs medical center.
Demonstrated improved differentiation between Clostridioides difficile infection and colonization.
Increased diagnostic accuracy for Clostridioides difficile-related infections.

Abstract

Abstract Clostridioides difficile infection is a common community and nosocomial infection. Two-stage testing (initial polymerase chain reaction (PCR) test, followed by a confirmatory toxin test for PCR+ results) has been used to help differentiate colonization from infection. We report the impact of adopting two-stage testing at a tertiary Veterans Affairs medical center.

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Cite This Study

Marker et al. (Thu,) studied this question.

synapsesocial.com/papers/6a23ba8771a5da9775e7638b https://doi.org/https://doi.org/10.1017/ash.2026.10427

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