Examines broad functional coverage in Streptococcus agalactiae, suggesting new insights into GBS biology and pathogenicity.
We present a comprehensive, in silico -designed CRISPR interference (CRISPRi) sgRNA database targeting the hypervirulent Streptococcus agalactiae strain COH1. This resource provides broad, redundant, and cross-strain functional coverage, enabling scalable CRISPRi-based interrogation of conserved and strain-specific determinants of GBS biology, colonization, and pathogenesis.
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Cutts et al. (2026) studied this question.
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