Correlation risk analysis of serum amyloid A, procalcitonin and IFN-β2 in A d verse outcom es of A cute pancreatitis

Background: To investigate the relationships between the severity and prognosis of individuals with acute pancreatitis (AP) and the levels of serum amyloid A, procalcitonin, and interferon-β2 (IFN-β2). Methods: 224 AP patients admitted to our hospital between February 2022 and February 2024 were selected as research participants. According to the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, the patients were divided into a mild AP group (140 patients) and a severe AP group (84 patients). The levels of serum amyloid A, CRP procalcitonin, and IFN-P 2 in the two groups were compared, and the relationships between these levels and the severity of the disease were analysed using Spearman correlation. The factors affecting the prognosis of AP patients were examined using binary logistic regression. Receiver operating characteristic (ROC) curves were used to evaluate the prognostic significance of serum amyloid A, CRP procalcitonin, and IFN-β2. Results: The levels of serum amyloid A, CRP procalcitonin and IFN-β2 in the mild AP group were significantly lower than those in the severe AP group (P< 0.05). The severity of AP was favourably connected with serum amyloid A, CRP procalcitonin, and IFN-β2 levels (r= 0.774, 0.678, 0.830, 0.584, P< 0.05). After 28 days of follow-up, among 224 AP patients, 64 patients (28.57% ) had poor prognoses, including 20 patients (8.93%) with respiratory insufficiency, 24 patients (10.71% ) with hypocalcemia, and 20 patients (8.93%) who died. The severe AP group also had a higher overall incidence of poor prognosis than the moderate AP group (P< 0.05). AP patients' poor prognosis was influenced by the APACHE II score and blood levels of serum amyloid A, CRP procalcitonin, and IFN-β2 (P< 0.05). According to the ROC curve analysis, the areas under the curve for predicting a poor AP prognosis were 0.859, 0.851, 0.811, and 0.802 for blood serum amyloid A, CRP procalcitonin, and IFN-β2, respectively, all of which had some predictive value. Conclusions: Serum amyloid A, CRP procalcitonin, and IFN-β2 levels show a strong prognostic value for AP patients' prognosis and are positively connected with the severity of AP.