Key result
Vascular endothelial cells act as semiprofessional antigen-presenting cells to drive T-cell activation and migration.
Design
Review
Vascular endothelial cells function as semiprofessional antigen-presenting cells that mediate T cell activation and transendothelial migration.
Vascular endothelial cells are implicated in allograft rejection, protection against pathogens, and lymphocyte recruitment from the bloodstream into sites of infection and inflammation. Endothelial cells have been termed 'semiprofessional' antigen-presenting cells because they co-stimulate T cell responses in vitro and because they are thought to stimulate alloresponses in vivo. Endothelial cells promote T cell transendothelial migration and activation, leading to tissue damage, such as vascular permeability, edema, and inflammation.
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Domenico Ribatti (2026) reported a review. Vascular endothelial cells act as 'semiprofessional' antigen-presenting cells that co-stimulate T cell responses and promote transendothelial migration and activation.
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