Immune response to the endothelium in myocarditis, dilated cardiomyopathy and rejection after heart transplantation
Key result
Moderate to severe rejection after heart transplantation was associated with significantly increased endothelial cell binding of Pal-E and F VIII-related antigen compared to other cardiac conditions.
Why the study?
Does binding of endothelial-specific antibodies differ in myocarditis, dilated cardiomyopathy, and heart transplant rejection compared to normal donor hearts?
Population
Endomyocardial biopsies from patients with myocarditis, dilated cardiomyopathy, no clinical rejection after…
Comparison
Staining with monoclonal endothelial-specific… vs 'Normal' donor hearts
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Endothelial antigen binding may mark severe rejection; leaves open whether these markers aid monitoring or therapy.
Study Design
Type
Cross-Sectional (n=56)
Structured PICO
Does binding of endothelial-specific antibodies differ in myocarditis, dilated cardiomyopathy, and heart transplant rejection compared to normal donor hearts?
P
Population
56 patients with myocarditis, dilated cardiomyopathy, or post-heart transplantation (with or without rejection) whose endomyocardial biopsies were examined.
E
Exposure
Staining with monoclonal endothelial-specific antibodies EN4, Pal-E and F VIII-related antigen
C
Comparator
'Normal' donor hearts
O
Outcome
Binding of antibodies EN4, Pal-E and F VIII-related antigensurrogate
Endothelial cells show increased expression of specific antigens during heart transplant rejection, suggesting they are important targets in the rejection process.
Cite This Study
Hengstenberg et al. (1991) conducted a cross-sectional in Myocarditis, dilated cardiomyopathy, and heart transplantation rejection (n=56). Moderate to severe rejection after heart transplantation vs. Myocarditis, dilated cardiomyopathy, no clinical rejection, and normal donor hearts was evaluated on Binding of monoclonal endothelial-specific antibodies EN4, Pal-E and F VIII-related antigen. Moderate to severe rejection after heart transplantation was associated with significantly increased endothelial cell binding of Pal-E and F VIII-related antigen compared to other cardiac conditions.