Key result
CD14-labeled macrophages and Fc gamma RIII cells are linked to heart allograft rejection.
Why the study?
The immunological characteristics of graft and infiltrating cells in endomyocardial biopsies after heart transplantation and their relation to rejection require further evaluation.
Population
104 endomyocardial biopsies from patients after heart transplantation
Comparison
Immunophenotyping for T-cell subsets, activation markers, and macrophages
Design
Observational study
Authors
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CD14+ macrophages and FcγRIII expression may aid rejection assessment in heart allografts; leaves open prospective validation before clinical use.
Observational (n=104)
Macrophage assessment, specifically using CD14 and Fc gamma RIII markers, is important in evaluating pathologic processes and diagnosing rejection in heart allografts.
Wijngaard et al. (1993) conducted an observational in Heart transplantation (n=104). Immunological markers (CD14, Fc gamma RIII, CD25) was evaluated on Histopathologic diagnosis of rejection. The numbers of macrophages labeled by CD14 and cells expressing Fc gamma RIII showed a significant relation to the histopathology of heart allograft rejection.
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