Key result
Granzyme B and perforin expression in biopsies is linked to acute rejection after heart transplant.
Why the study?
Histological analysis is the standard for monitoring rejection in heart transplant patients, but the role of granzyme B and perforin as markers for acute rejection needed characterization.
Does the detection of perforin and granzyme B in endomyocardial biopsies predict acute rejection in heart transplant patients?
Population
14 heart transplant patients with 42 endomyocardial biopsies
Comparison
Presence versus absence of granzyme B and perforin in biopsies
Design
Observational study using in situ hybridization on EMB samples
Follow-up
Up to 960 days post-graft
Authors
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EMB histology may aid rejection monitoring after heart transplant; leaves open immunological differences between early and late crises.
Observational (n=14)
Does the detection of perforin and granzyme B in endomyocardial biopsies predict acute rejection in heart transplant patients?
Granzyme B and perforin expression in endomyocardial biopsies may serve as predictive markers for early acute rejection and help guide corticosteroid therapy in heart transplant recipients.
Clement et al. (1991) conducted an observational in Heart transplantation (n=14). Granzyme B and perforin expression was evaluated on Acute rejection. Granzyme B and perforin expression in endomyocardial biopsies may serve as predictive markers for acute rejection in heart transplant patients with early rejection crisis.
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