Why the study?
Does the detection of perforin and granzyme B expression in graft-infiltrating lymphocytes predict acute rejection in heart transplant patients?
Population
28 patients who underwent heart transplantation (103 endomyocardial biopsies)
Design
Cohort
Authors
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May support perforin/granzyme B as biomarkers for rejection progression in heart transplant; leaves open prospective validation before clinical adoption.
Does the detection of perforin and granzyme B expression in graft-infiltrating lymphocytes predict acute rejection in heart transplant patients?
Granzyme B and perforin expression in graft-infiltrating lymphocytes may serve as useful predictive biomarkers for acute rejection and its progression in heart transplant patients.
Legros-Maïda et al. (1994) studied this question.
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