Key result
Tolerized mouse heart grafts pretreated with donor-specific transfusion and/or anti-CD4 monoclonal antibody showed decreased granzyme A and perforin expression compared to untreated allografts.
Why the study?
Does pretreatment with donor-specific transfusion and/or anti-CD4 monoclonal antibody reduce the expression of granzyme A and perforin in a mouse cardiac transplant model?
Population
Mouse cardiac transplant model
Comparison
Pretreatment with donor-specific transfusion… vs Untreated allografts
Design
Preclinical
Authors
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Supports granzyme A/perforin as tolerance markers in murine grafts; leaves open translation to clinical transplantation.
Does pretreatment with donor-specific transfusion and/or anti-CD4 monoclonal antibody reduce the expression of granzyme A and perforin in a mouse cardiac transplant model?
Granzyme A and perforin expression can differentiate between rejecting and indefinitely surviving cardiac grafts in a mouse model, serving as functional markers of cytotoxic T lymphocytes.
Chen et al. (1996) studied Heart transplant rejection. Donor-specific transfusion and/or anti-CD4 monoclonal antibody vs. Untreated allografts was evaluated on Frequency of granzyme A and perforin expression. Tolerized mouse heart grafts pretreated with donor-specific transfusion and/or anti-CD4 monoclonal antibody showed decreased granzyme A and perforin expression compared to untreated allografts.
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