August 2, 1991European Heart Journal
Immunocytochemical markers of activation in cardiac transplant rejection
Key result
Cardiac transplant rejection is linked to increased myocardial ICAM-1 and capillary endothelial antigen expression.
Why the study?
Immunocytochemical changes in antigen expression on myocardium and endothelium characteristic of cardiac transplant rejection have been defined but require further characterization.
Population
Endomyocardial biopsies from cardiac transplant patients and normal donor hearts
Comparison
Biopsies with histological signs of rejection vs normal donor heart biopsies
Design
Observational immunocytochemical analysis
Authors
Discussion
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Implication
May inform immunohistochemical assessment of cardiac allograft rejection; leaves open whether these changes predict outcomes or alter management.
Study Design
Type
Observational
PICO
P
Population
Endomyocardial biopsies from cardiac transplant patients showing histological signs of rejection compared with normal donor heart biopsies.
E
Exposure / Comparator
Cardiac transplant rejection vs Normal donor heart biopsies
O
Primary Outcome
Expression of antigens on myocardium and endothelium
Cite This Study
Rose et al. (1991) conducted an observational in Cardiac transplant rejection. Cardiac transplant rejection vs. Normal donor heart biopsies was evaluated on Expression of antigens on myocardium and endothelium. Cardiac transplant rejection was associated with induction of MHC class I and ICAM-1 on the myocardium and increased expression of Pal-E and FVIII-RA on capillary endothelial cells.