Key result
Elevated T-cell expression of early and late activation markers did not reliably indicate acute graft rejection in heart transplant recipients, yielding an overall accuracy of 43%.
Why the study?
Does the expression of early and late activation markers on peripheral blood T lymphocytes reliably reflect acute graft rejection in heart transplant recipients?
Population
Heart transplant recipients, with control groups of patients awaiting cardiac transplantation and kidney…
Comparison
Monitoring of early and late activation markers… vs Patient control groups and healthy control…
Design
Cohort
Follow-up
>6 months
Authors
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T-cell activation markers lack diagnostic utility for acute rejection; hypothesis-generating for reliable noninvasive monitoring strategies in heart transplantation.
Observational (n=60)
Does the expression of early and late activation markers on peripheral blood T lymphocytes reliably reflect acute graft rejection in heart transplant recipients?
Effect estimate: Sensitivity 38%, specificity 52%, accuracy 43%
Expression of early and late activation markers on peripheral blood T lymphocytes does not reliably correlate with acute graft rejection in heart transplant recipients, highlighting the need for appropriate patient control populations.
Loertscher et al. (1994) conducted an observational in Cardiac transplantation (n=60). Peripheral blood T lymphocyte activation markers (IL-2R, TfR, VLA-1, PTAI) vs. Patient control groups (awaiting heart transplant, kidney transplant recipients) was evaluated on Acute graft rejection (Sensitivity 38%, specificity 52%, accuracy 43%). Elevated T-cell expression of early and late activation markers did not reliably indicate acute graft rejection in heart transplant recipients, yielding an overall accuracy of 43%.
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